Video Summary

As the NFL season approaches its mid-point, two top-10 teams face off in a crucial Thursday Night Football matchup. The Seattle Seahawks, coming off a tough loss to the Giants, will host the San Francisco 49ers, who are seeking redemption after a heartbreaking defeat against Arizona.

For the Seahawks to cover or win, they'll need to dominate both offensive and defensive running games. With the 49ers having struggled against the run, Seattle's Kenneth Walker and Shane Walton could find success, especially in man scheme plays. However, San Francisco's top-10 defensive unit will look to shut down the Seahawks' zone runs.

On the other side, the 49ers, led by quarterback Brock Purdy, will need to find ways to exploit Seattle's vulnerable pass defense. Purdy's steady hand will be crucial, and his ability to make quick decisions could lead to success. The 49ers' aerial attack, led by Auk DeBo, KD Yan, and others, will look to take advantage of Seattle's aggressiveness, as the Seahawks send pressure on cue.

The spread lean is in favor of the 49ers, who, despite their 2-3 record, are viewed as the better team. The final score will likely be close, with the 49ers covering the 3.5-point spread. However, if the Seahawks can control the tempo with their running backs, they may find themselves in a position to keep it close. The under/over total is also worth monitoring, with both teams boasting top-10 rates of offensive plays per minute. A high-scoring game is expected, with the over leaning toward 47.5.